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Aktuelle Publikationen der Reproductive Biology Unit

2021

Heparin-binding motif mutations of human diamine oxidase allow the development of a first-in-class histamine-degrading biopharmaceutical.

Gludovacz E, Schuetzenberger K, Resch M, Tillmann K, Petroczi K, Schosserer M, Vondra S, Vakal S, Klanert G, Pollheimer J, Salminen TA, Jilma B, Borth N, Boehm T.

Elife. 2021 Sep 3;10:e68542. doi: 10.7554/eLife.68542.PMID: 34477104 

 

MSX2 safeguards syncytiotrophoblast fate of human trophoblast stem cells.

Hornbachner R, Lackner A, Papuchova H, Haider S, Knöfler M, Mechtler K, Latos PA.

Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2105130118. doi: 10.1073/pnas.2105130118. PMID: 34507999; PMCID: PMC8449346.

 

PRG2 and AQPEP are misexpressed in fetal membranes in placenta previa and percreta†.

Zhang ET, Hannibal RL, Badillo Rivera KM, Song JHT, McGowan K, Zhu X, Meinhardt G, Knöfler M, Pollheimer J, Urban AE, Folkins AK, Lyell DJ, Baker JC

Biol Reprod. 2021 Jul 2;105(1):244-257. doi: 10.1093/biolre/ioab068. PMID: 33982062; PMCID: PMC8256106.

 

Decidual stromal cells support tolerance at the human foetal-maternal interface by inducing regulatory M2 macrophages and regulatory T-cells.

Lindau R, Vondra S, Spreckels J, Solders M, Svensson-Arvelund J, Berg G, Pollheimer J, Kaipe H, Jenmalm MC, Ernerudh J.

J Reprod Immunol. 2021 Aug;146:103330. doi: 10.1016/j.jri.2021.103330. Epub 2021 May 12.PMID: 34049032 

 

Human diamine oxidase cellular binding and internalization in vitro and rapid clearance in vivo are not mediated by N-glycans but by heparan sulfate proteoglycan interactions.

Gludovacz E, Schuetzenberger K, Resch M, Tillmann K, Petroczi K, Vondra S, Vakal S, Schosserer M, Virgolini N, Pollheimer J, Salminen TA, Jilma B, Borth N, Boehm T.

Glycobiology. 2021 May 3;31(4):444-458. doi: 10.1093/glycob/cwaa090.PMID: 32985651

3-Dimensional JEG-3 choriocarcinoma cell organoids as a model for trophoblast expansion and differentiation.

Dietrich B, Kunihs V, Haider S, Pollheimer J, Knöfler M.

Placenta. 2021 Jan 15;104:243-246. doi: 10.1016/j.placenta.2020.12.013. Epub 2020 Dec 28.PMID: 33461068

 

2020

Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem Cells

Castel G, Meistermann D, Bretin B, Firmin J, Blin J, Loubersac S, Bruneau A, Chevolleau S, Kilens S, Chariau C, Gaignerie A, Francheteau Q, Kagawa H, Charpentier E, Flippe L, François-Campion V, Haider S, Dietrich B, Knöfler M, Arima T, Bourdon J, Rivron N, Masson D, Fournier T, Okae H, Fréour T, David L.

Cell Rep. 2020 Nov 24;33(8):108419. doi: 10.1016/j.celrep.2020.108419. PMID: 33238118 Free article.

 

Densities of decidual high endothelial venules correlate with T-cell influx in healthy pregnancies and idiopathic recurrent pregnancy losses

Windsperger K, Vondra S, Lackner AI, Kunihs V, Haslinger P, Meinhardt G, Dietrich B, Dekan S, Fiala C, Knöfler M, Saleh L, Pollheimer J.

Hum Reprod. 2020 Nov 1;35(11):2467-2477. doi: 10.1093/humrep/deaa234.

 

Matrix metalloproteinase 15 plays a pivotal role in human first trimester cytotrophoblast invasion and is not altered by maternal obesity

Majali-Martinez A, Hoch D, Tam-Amersdorfer C, Pollheimer J, Glasner A, Ghaffari-Tabrizi-Wizsy N, Beristain AG, Hiden U, Dieber-Rotheneder M, Desoye G.

FASEB J. 2020 Aug;34(8):10720-10730. doi: 10.1096/fj.202000773R. Epub 2020 Jul 2. PMID: 32614494 Free PMC article.

 

Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta

Meinhardt G, Haider S, Kunihs V, Saleh L, Pollheimer J, Fiala C, Hetey S, Feher Z, Szilagyi A, Than NG, Knöfler M.

Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13562-13570. doi: 10.1073/pnas.2002630117. Epub 2020 Jun 1. PMID: 32482863 Free PMC article.

 

Barusiban, a selective oxytocin receptor antagonist: placental transfer in rabbit, monkey, and human

Helmer H, Saleh L, Petricevic L, Knöfler M, Reinheimer TM.

Biol Reprod. 2020 Jun 23;103(1):135-143. doi: 10.1093/biolre/ioaa048. PMID: 32307542 Free PMC article.

 

STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer

Oberhuber M, Pecoraro M, Rusz M, Oberhuber G, Wieselberg M, Haslinger P, Gurnhofer E, Schlederer M, Limberger T, Lagger S, Pencik J, Kodajova P, Högler S, Stockmaier G, Grund-Gröschke S, Aberger F, Bolis M, Theurillat JP, Wiebringhaus R, Weiss T, Haitel A, Brehme M, Wadsak W, Griss J, Mohr T, Hofer A, Jäger A, Pollheimer J, Egger G, Koellensperger G, Mann M, Hantusch B, Kenner L.

Mol Syst Biol. 2020 Apr;16(4):e9247. doi: 10.15252/msb.20199247. PMID: 32323921 Free PMC article.

 

Ropivacaine Activates Multiple Proapoptotic and Inflammatory Signaling Pathways That Might Subsume to Trigger Epidural-Related Maternal Fever

Wohlrab P, Boehme S, Kaun C, Wojta J, Spittler A, Saleh L, Knöfler M, Markstaller K, Klein KU, Tretter V.

Anesth Analg. 2020 Feb;130(2):321-331. doi: 10.1213/ANE.0000000000004402. PMID: 31498191

 

Placenta-Specific Genes, Their Regulation During Villous Trophoblast Differentiation and Dysregulation in Preterm Preeclampsia

Szilagyi A, Gelencser Z, Romero R, Xu Y, Kiraly P, Demeter A, Palhalmi J, Gyorffy BA, Juhasz K, Hupuczi P, Kekesi KA, Meinhardt G, Papp Z, Draghici S, Erez O, Tarca AL, Knöfler M, Than NG.

Int J Mol Sci. 2020 Jan 17;21(2):628. doi: 10.3390/ijms21020628. PMID: 31963593 Free PMC article.

 

2019

Metabolism of cholesterol and progesterone is differentially regulated in primary trophoblastic subtypes and might be disturbed in recurrent miscarriages.

Vondra S, Kunihs V, Eberhart T, Eigner K, Bauer R, Haslinger P, Haider S, Windsperger K, Klambauer G, Schütz B, Mikula M, Zhu X, Urban AE, Hannibal RL, Baker J, Knöfler M, Stangl H, Pollheimer J, Röhrl C.

J Lipid Res. 2019 Nov;60(11):1922-1934. doi: 10.1194/jlr.P093427. Epub 2019 Sep 17.

 

Estrogen Signaling Drives Ciliogenesis in Human Endometrial Organoids.

Haider S, Gamperl M, Burkard TR, Kunihs V, Kaindl U, Junttila S, Fiala C, Schmidt K, Mendjan S, Knöfler M, Latos PA.

Endocrinology. 2019 Oct 1;160(10):2282-2297. doi: 10.1210/en.2019-00314.

 

Human placenta and trophoblast development: key molecular mechanisms and model systems.

Knöfler M, Haider S, Saleh L, Pollheimer J, Gamage TKJB, James J.

Cell Mol Life Sci. 2019 Sep;76(18):3479-3496. doi: 10.1007/s00018-019-03104-6. Epub 2019 May 3. Review.

 

2018

Regulation of Placental Extravillous Trophoblasts by the Maternal Uterine Environment

Pollheimer J, Vondra S, Baltayeva J, Beristain AG, Knöfler M

Front Immunol; 2018 Nov 13 (9):2597

 

Genome amplification and cellular senescence are hallmarks of human placenta development

Velicky P, Meinhardt G, Plessl K, Vondra S, Weiss T, Haslinger P, Lendl T, Aumayr K, Mairhofer M, Zhu X, Schütz B, Hannibal RL, Lindau R, Weil B, Ernerudh J, Neesen J, Egger G, Mikula M, Röhrl C, Urban AE, Baker J, Knöfler M, Pollheimer J

PLoS Genet; 2018 Oct 12 (14(10)):e1007698

 

Human trophoblast invasion: new and unexpected routes and functions

Moser G, Windsperger K, Pollheimer J, de Sousa Lopes SC, Huppertz B

Histochem Cell Biol; 2018 Oct (150(4)):361-370

 

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta

Haider S, Meinhardt G, Saleh L, Kunihs V, Gamperl M, Kaindl U, Ellinger A, Burkard TR, Fiala C, Pollheimer J, Mendjan S, Latos PA, Knöfler M

Stem Cell Reports, 2018 Aug 14 (11(2)):537-551

 

Pregnancy-associated diamine oxidase originates from extravillous trophoblasts and is decreased in early-onset preeclampsia

Velicky P, Windsperger K, Petroczi K, Pils S, Reiter B, Weiss T, Vondra S, Ristl R, Dekan S, Fiala C, Cantonwine DE, McElrath TF, Jilma B, Knöfler M, Boehm T, Pollheimer J

Sci Rep; 2018 Apr 20 (8(1)):6342

 

2017

Expression pattern and phosphorylation status of Smad2/3 in different subtypes of human first trimester trophoblast.

Haider S, Kunihs V, Fiala C, Pollheimer J, Knöfler M.

Placenta. 2017 Sep;57:17-25. doi: 10.1016/j.placenta.2017.06.003.

 

Extravillous trophoblast invasion of venous as well as lymphatic vessels is altered in idiopathic, recurrent, spontaneous abortions.

Windsperger K, Dekan S, Pils S, Golletz C, Kunihs V, Fiala C, Kristiansen G, Knöfler M, Pollheimer J.

Hum Reprod. 2017 Jun 1;32(6):1208-1217. doi: 10.1093/humrep/dex058.

 

Chymase-producing cells of the innate immune system are required for decidual vascular remodeling and fetal growth.

Meyer N, Woidacki K, Knöfler M, Meinhardt G, Nowak D, Velicky P, Pollheimer J, Zenclussen AC.

Sci Rep. 2017 Mar 22;7:45106. doi: 10.1038/srep45106.

 

Notch signalling in placental development and gestational diseases.

Haider S, Pollheimer J, Knöfler M.

Placenta. 2017 Aug;56:65-72. doi: 10.1016/j.placenta.2017.01.117. Epub 2017 Jan 16.

 

Endothelin-1 down-regulates matrix metalloproteinase 14 and 15 expression in human first trimester trophoblasts via endothelin receptor type B.

Majali-Martinez A, Velicky P, Pollheimer J, Knöfler M, Yung HW, Burton GJ, Tabrizi-Wizsy NG, Lang U, Hiden U, Desoye G, Dieber-Rotheneder M.

Hum Reprod. 2017 Jan;32(1):46-54.

 

2016

Granulocytic Myeloid-Derived Suppressor Cells Accumulate in Human Placenta and Polarize toward a Th2 Phenotype.

Köstlin N, Hofstädter K, Ostermeir AL, Spring B, Leiber A, Haen S, Abele H, Bauer P, Pollheimer J, Hartl D, Poets CF, Gille C.

J Immunol. 2016 Feb 1;196(3):1132-45. doi: 10.4049/jimmunol.1500340.

 

Notch1 controls development of the extravillous trophoblast lineage in the human placenta.

Haider S, Meinhardt G, Saleh L, Fiala C, Pollheimer J, Knöfler M.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7710-E7719.

 

Wingless ligand 5a is a critical regulator of placental growth and survival.

Meinhardt G, Saleh L, Otti GR, Haider S, Velicky P, Fiala C, Pollheimer J, Knöfler M.

Sci Rep. 2016 Jun 17;6:28127. doi: 10.1038/srep28127.

 

Epithelial-mesenchymal transition during extravillous trophoblast differentiation.

E Davies J, Pollheimer J, Yong HE, Kokkinos MI, Kalionis B, Knöfler M, Murthi P.

Cell Adh Migr. 2016 May 3;10(3):310-21. doi: 10.1080/19336918.2016.1170258.

 

Function and control of human invasive trophoblast subtypes: Intrinsic vs. maternal control.

Velicky P, Knöfler M, Pollheimer J.

Cell Adh Migr. 2016 Mar 3;10(1-2):154-62. doi: 10.1080/19336918.2015.1089376.

 

Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters.

Straka E, Ellinger I, Balthasar C, Scheinast M, Schatz J, Szattler T, Bleichert S, Saleh L, Knöfler M, Zeisler H, Hengstschläger M, Rosner M, Salzer H, Gundacker C.

Toxicology. 2016 Jan 18;340:34-42. doi: 10.1016/j.tox.2015.12.005.

 

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